Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
Sizuo Kajiyama, Goji Hasegawa, Mai Asano, Hiroko Hosoda, Michiaki Fukui, Naoto Nakamura, Jo Kitawaki, Saeko Imai, Koji Nakano, Mitsuhiro Ohta, Tetsuo Adachi, Hiroshi Obayashi, Toshikazu Yoshikawa · Nutrition research (New York, N.Y.) · 2008
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Independent study record
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H2HUBB TAKEAWAY
In 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT, hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase.
What the Researchers Studied
The study examined 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT.
How Molecular Hydrogen Was Used
The patients consumed either 900 mL/d of hydrogen-rich pure water or 900 mL of placebo pure water for 8 weeks, with a 12-week washout period.
What the Researchers Found
Intake of hydrogen-rich water was associated with significant decreases in the levels of modified low-density lipoprotein (LDL) cholesterol (ie, modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15.5% (P <.01), 5.7% (P <.05), and 6.6% (P <.05), respectively. Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase.
H₂ Mechanisms / Biological Findings
The source material reviewed did not establish a specific molecular hydrogen mechanism for the reported findings.
Authors’ Conclusion
The authors concluded that , these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance.