Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
Sizuo Kajiyama, Goji Hasegawa, Mai Asano, Hiroko Hosoda, Michiaki Fukui, Naoto Nakamura, Jo Kitawaki, Saeko Imai, Koji Nakano, Mitsuhiro Ohta, Tetsuo Adachi, Hiroshi Obayashi, Toshikazu Yoshikawa · Nutrition research (New York, N.Y.) · 2008
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT, hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence glucose regulation and metabolic health.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT. Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase.
What the Researchers Studied
The researchers studied 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT. The study used a randomized, double-blind, placebo-controlled, crossover human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 900 mL hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂; reported treatment duration: 8 weeks. Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase. The authors concluded that in conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence glucose regulation and metabolic health and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled, crossover human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT. The reported sample size was 30. The study used a randomized, double-blind, placebo-controlled, crossover human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen exposure was 900 mL hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂. The reported treatment duration was 8 weeks.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.