The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments during High-Intensity Intermittent Exercise in Humans.
Ahad Abdulkarim D Alharbi, Noriaki Iwamoto, Naoyuki Ebine, Satoshi Nakae, Tatsuya Hojo, Yoshiyuki Fukuoka · Nutrients · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The results of this study demonstrated that the ingestion of an H₂-rich calcium powder supplement increased the subjects’ PCO 2 and HCO 3 − concentrations at rest and improved the peak power in the 1st bout of the HIIT protocol. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence exercise performance and recovery in healthy men.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 10 healthy, trained participants. The results of this study demonstrated that the ingestion of an H₂-rich calcium powder supplement increased the subjects’ PCO 2 and HCO 3 − concentrations at rest and improved the peak power in the 1st bout of the HIIT protocol.
What the Researchers Studied
The researchers studied 10 healthy, trained participants. The study used a randomized, double-blind, placebo-controlled, crossover human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Using a crossover double-blind design, the subjects were examined twice and given a single dose of four capsules of either an H₂-rich calcium powder (HCP) supplement (ENAGEGATE, Tokyo, Japan) or calcium powder as a placebo (ENAGEGATE) 1 h before the experiment ( Figure 1 A). The results of this study demonstrated that the ingestion of an H₂-rich calcium powder supplement increased the subjects’ PCO 2 and HCO 3 − concentrations at rest and improved the peak power in the 1st bout of the HIIT protocol.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence exercise performance and recovery in healthy men and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled, crossover human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 10 healthy, trained participants. The reported sample size was 10. The study used a randomized, double-blind, placebo-controlled, crossover human clinical trial.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.