The Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline against N-Methyl-N-Nitrosourea Induced Retinal Degeneration: A Topographic Study.
Ye Tao, Tao Chen, Wei Fang, Zhongjun Yan, Qinghua Yang, Yifei Huang, Linjun Yu, Lingling Fan · Frontiers in pharmacology · 2017
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Independent study record
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H2HUBB TAKEAWAY
In rats, fIGURE 4 Hydrogen rich saline induced effects on the oxygen stress markers of MNU administered rats. (A) The SOD level of the untreated group was significantly lower than the IV and IP treated group ( P < 0.01). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in rats. FIGURE 4 Hydrogen rich saline induced effects on the oxygen stress markers of MNU administered rats. (A) The SOD level of the untreated group was significantly lower than the IV and IP treated group ( P < 0.01).
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Hydrogen rich saline was prepared following previously described protocols ( Ohsawa et al., 2007 ). Under hyperbaric conditions (0.4 MPa), hydrogen was dissolved in physiological saline for 6 h. The hydrogen level in the saline was assessed by gas chromatography to ensure it reach the supersaturated level. FIGURE 4 Hydrogen rich saline induced effects on the oxygen stress markers of MNU administered rats. (A) The SOD level of the untreated group was significantly lower than the IV and IP treated group ( P < 0.01). The authors concluded that the IV space is an excellent target for HRS delivery. The present study explored the protective effects of hydrogen rich saline (HRS) against the photoreceptor degeneration in the N-Methyl-N-nitrosourea (MNU) administrated rat, a pharmacologically induced RP model. Hydrogen is recognized as a therapeutic agent based on its capability to selectively neutralize the cytotoxic ROS and relieve the detrimental oxidative stress ( Ohsawa et al., 2007 ) has been used in numerous medical applications to counteract pathologies, such as the ischemia–reperfusion injuries cognitive deficits, metabolic syndromes, inflammatory diseases and so on ( Huang et al., 2010; Oláh et al., 2013; Terawaki et al., 2013; Ohta, 2015 ).
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.