The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial.
Tyler W LeBaron, Ram B Singh, Ghizal Fatima, Kumar Kartikey, Jagdish P Sharma, Sergej M Ostojic, Anna Gvozdjakova, Branislav Kura, Mami Noda, Viliam Mojto, Mohammad Arif Niaz, Jan Slezak · Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 60 participants (30 men and 30 women) with metabolic syndrome, supplementation with high-concentration HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to placebo.
What the Researchers Studied
Pre-clinical and clinical studies have shown promising effects of H₂-rich water (HRW) on specific features of metabolic syndrome, yet the effects of long-term, high-concentration HRW in this prevalent condition remain poorly addressed.
How Molecular Hydrogen Was Used
Molecular hydrogen was administered as high-concentration hrw (> 5.5 millimoles of h₂ per day) for 24 weeks.
What the Researchers Found
Supplementation with high-concentration HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to placebo (P < 0.05).
H₂ Mechanisms / Biological Findings
Molecular hydrogen (H₂) may attenuate oxidative stress, improve cellular function, and reduce chronic inflammation.
Authors’ Conclusion
The authors concluded that high-concentration HRW might have promising effects as a therapeutic modality for attenuating risk factors of metabolic syndrome.