The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial.
Jovan Kuzmanovic, Nikola Todorovic, Marijana Ranisavljev, Dejan Javorac, Darinka Korovljev, Alex Tarnava, Valdemar Stajer, Sergej M Ostojic · Research in sports medicine (Print) · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 27 apparently healthy, middle-aged participants (18 women), HRW significantly outperformed the control water in reducing biomarkers of acute muscular damage caused by resistance exercise (p ≤ 0.05); the sleep quality difference favored HRW but was not statistically significant (p = 0.119). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 27 apparently healthy, middle-aged participants (18 women). HRW significantly outperformed the control water in reducing biomarkers of acute muscular damage caused by resistance exercise (p ≤ 0.05); the sleep quality difference favored HRW but was not statistically significant (p = 0.119).
What the Researchers Studied
The researchers studied 27 apparently healthy, middle-aged participants (18 women). The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 0.1 mg/L H₂. HRW significantly outperformed the control water in reducing biomarkers of acute muscular damage caused by resistance exercise (p ≤ 0.05); the sleep quality difference favored HRW but was not statistically significant (p = 0.119).
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 27 apparently healthy, middle-aged participants (18 women). The reported sample size was 18. The study used a randomized, double-blind, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 0.1 mg/L H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.