The impact of hydrogen-rich water on liver enzyme levels in clinical populations: a comprehensive review and meta-analysis.
Ghazaleh Khalili-Tanha, Hamid Jamialahmadi, Mostafa Rezaei-Tavirani, Elham Nazari · Gastroenterology and hepatology from bed to bench · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The results showed a slight decrease in ALT, AST, and ALP levels in the treated group with HRW compared to the PW group. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. The results showed a slight decrease in ALT, AST, and ALP levels in the treated group with HRW compared to the PW group.
What the Researchers Studied
The study used a meta analysis. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
The results showed a slight decrease in ALT, AST, and ALP levels in the treated group with HRW compared to the PW group. The authors concluded that consuming HRW may decrease liver enzyme levels in clinical populations. Twenty-three T2DM patients were treated with electrolyzed hydrogen-rich water (EHW) to see how hydrogen affected oxidative stress.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a meta analysis. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The reported sample size was 433. The study used a meta analysis. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
Reported limitations: the heterogeneity assessment showed heterogeneity with I 2 = 99.68%. as seen in Figure 2 (I 2 = 98%), heterogeneity was noted in these studies. ALP enzyme changes after treatment with HRW in different liver dysfunctions were evaluated based on random effect heterogeneity in all 8 studies.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.