The impact of perioperative hydrogen gas inhalation on postoperative recovery in day surgery patients: a research study.
Shuman Ji, Qianqian Xiao, Bohua Zhang, Runlu Cai, Yayu Jing, Duomin Yang, Ni Liu, Zhanqin Zhang, Xiaopeng Mei · Scientific reports · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In exploratory analyses, the hydrogen group also showed descriptive trends toward lower pain scores, greater physical independence, and improved sleep quality.
What the Researchers Studied
150 patients with 76 in the hydrogen group and 74 in the control group.
How the Study Was Conducted
Randomized, double-blind human clinical trial.
How Molecular Hydrogen Was Used
This prospective, double-blind, randomized controlled trial was conducted at a day surgery center to evaluate whether perioperative hydrogen inhalation improves recovery outcomes in patients undergoing laparoscopic cholecystectomy or thyroidectomy. Patients were randomly assigned to receive either a hydrogen-oxygen mixture (containing 66.7% hydrogen) or a nitrogen-oxygen mixture (containing 66.7% nitrogen) via nasal cannula before and after surgery. A total of 150 patients were enrolled, with 76 in the hydrogen group and 74 in the control group.
What the Researchers Found
In exploratory analyses, the hydrogen group also showed descriptive trends toward lower pain scores, greater physical independence, and improved sleep quality.
Authors’ Conclusion
The authors concluded that perioperative hydrogen inhalation may alleviate inflammatory stress and promote recovery in patients undergoing day surgery.