Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis.
Jiaxuan He, Peiye Xu, Ting Xu, Haiyang Yu, Lei Wang, Rongbing Chen, Kun Zhang, Yueliang Yao, Yanyan Xie, Qinsi Yang, Wei Wu, Da Sun, Dejun Wu · Frontiers in aging neuroscience · 2024
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Independent study record
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H2HUBB TAKEAWAY
In mice, biochemical indicators showed that pro-inflammatory factors IL-6 ( p < 0.01), IL-1β ( p < 0.001), and TNF-α ( p < 0.01), decreased. The anti-inflammatory factor IL-10 increased ( p < 0.05) in the brains of zebrafish treated with HRW in Figures 6D – G, indicating that HRW improved the inflammatory microenvironment in the brains under AD conditions. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in mice. Biochemical indicators showed that pro-inflammatory factors IL-6 ( p < 0.01), IL-1β ( p < 0.001), and TNF-α ( p < 0.01), decreased, while the anti-inflammatory factor IL-10 increased ( p < 0.05) in the brains of zebrafish treated with HRW in Figures 6D – G, indicating that HRW improved the inflammatory microenvironment in the brains under AD conditions.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 000 ppb H₂ (≈0 mg/L); reported treatment duration: 1 month. Biochemical indicators showed that pro-inflammatory factors IL-6 ( p < 0.01), IL-1β ( p < 0.001), and TNF-α ( p < 0.01), decreased, while the anti-inflammatory factor IL-10 increased ( p < 0.05) in the brains of zebrafish treated with HRW in Figures 6D – G, indicating that HRW improved the inflammatory microenvironment in the brains under AD conditions. The authors concluded that HRW has potential as a therapeutic strategy for AD by targeting oxidative stress, inflammation, and gut-brain axis modulation. Given hydrogen’s well-documented antioxidant properties, including its ability to scavenge hydroxyl radicals and reduce oxidative damage, its therapeutic potential has been explored in conditions ranging from multi-organ ischemia/reperfusion injury to neurodegenerative diseases like AD, osteoarthritis, and respiratory diseases ( Yuan et al., 2023 ). The mechanism of hydrogen in this paper is shown in Figure 10.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 000 ppb H₂ (≈0 mg/L). The reported treatment duration was 1 month.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.