Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In ICR mice with lipopolysaccharide-induced inflammation-related behavioral changes, however, therapy with H₂ increased the survival rate and alleviated the severity of lung injury, reduced the HMGB1 level, and increased the HO-1 and Nrf2 levels in septic mice. These preclinical findings add evidence…
Read ArticleIn mice, H₂ therapy in the animals with severe sepsis was associated with reduced intestinal injury, decreased numbers of colony-forming unit and apoptotic cells, reduced levels of biochemical…
Read ArticleIn male C57BL/6 mice, lung HE staining showed that there were obvious lung injuries in the sepsis group which were alleviated in the H₂ treatment group. These preclinical…
Read ArticleIn female Sprague-Dawley rats, inhaled H₂ improved hemodynamics and right heart function, reversed right ventricular hypertrophy, and prevented pulmonary vessel reconstitution in both prevention and treatment approaches. These…
Read ArticleIn vitro experiments showed that hydrogen from AMASS degradation significantly inhibited tumor proliferation, increased apoptosis, disrupted redox homeostasis and mitochondrial membrane potential, reduced adenosine triphosphate levels, and induced…
Read ArticleIn The human ovarian cancer cell line SKOV3 was obtained from Central laboratory of the Affiliated Taian City Central Hospital of Qingdao University, at the same time, hydrogen…
Read ArticleIn rats, the H₂ group preserved ERK expression, whereas the CTRL and H₂ + 3-MA groups showed remarkably reduced ERK expression. *: statistical significance with p < 0.001…
Read ArticleThis narrative review examined the researchers conducted a literature review to examine the relationship between hearing loss and ROS/free radicals in both humans and animal models. Antioxidant strategies…
Read ArticleIn an animal model, the mRNA levels of apoptosis-inducing factor and caspase-3 showed a ~10-fold increase in the A-HT group compared to naïve animals in the hippocampus but…
Read ArticleIn mice, H₂ treatment increased survival rates, mitigated cognitive impairment, reduced hippocampal histological damage, decreased EB and water content, and decreased the levels of TNF-α, IL-6, HMGB1, Nrf2,…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. The increased evidence obtained from cultured cells or animal experiments reveal a putative place for H₂ treatment and its radioprotective…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Recently, the pathophysiological effects of inhaled gases including nitric oxide (NO), molecular hydrogen (H₂), and xenon (Xe) have attracted much…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Safety of both Xe and H₂ after cardiac arrest has been reported in phase 1 clinical trials. The reviewed evidence…
Read ArticleIn rats, on the 14th day, aggregation in the group with multiple exposures to H₂ was restored to the values of the intact group; with a single exposure,…
Read ArticleIn rats, molecular hydrogen improved the weight, survival and long-term neurological function of rats with diabetic stroke and alleviated changes in blood glucose levels before and after middle…
Read Article