Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen.
In a small randomized crossover study of 10 human participants, a persistent H₂-generating supplement increased exhaled H₂ and improved tear stability and dry-eye symptoms. Supporting mouse experiments found increased tear secretion and less tear reduction in a dry-eye model. The human findings are exploratory because of the small sample, and larger trials are needed.
Read MoreElectrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients.
This controlled human trial examined Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. The abstract describes Human participants; sample size 15; reported duration 6 month. The abstract reports: The patients showed marked increases (15-fold) in blood reactive oxygen species, mostly H(2)O(2), after HD without any treatment. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreImproved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study.
This uncontrolled human study examined Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: The extent of the initial hump of rDWI, the initial dip of rADC and pseudo-normalization time were determined in each patient serially and averages…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline.
This uncontrolled human study examined Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. The abstract describes Human participants. The abstract reports: These findings provided direct evidence supporting the notion that CS exposure in vivo impairs plasma lipid profiles, HDL functionalities and macrophage-to-feces RCT pathway in…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans.
BackgroundHydrogen gas inhalation (HI) reduced infarct size and mitigated adverse left ventricular (LV) remodeling in a rat model of acute myocardial infarction (AMI). We designed a prospective, open-label, rater-blinded clinical pilot study in patients experiencing ST-elevated MI (STEMI).Methods and resultsThe 20 patients with an initial diagnosis of STEMI were assigned to either an HI group (1.3% H2with 26% oxygen) or a control group (26% oxygen). There were no HI-related severe adverse events.
Read MoreHydrogen-rich electrolyzed water is a useful mouthwash due to its biofilm-control properties: an in vitro and in vivo study
This uncontrolled human study examined Hydrogen-rich electrolyzed water is a useful mouthwash due to its biofilm-control properties: an in vitro and in vivo study. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Our data suggest that oral rinsing with HEW exerts antibiofilm effects on S. mutans, indicating that it can be used as a mouthwash to…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAtomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo.
This animal study examined Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. The abstract describes Animal model. The abstract reports: We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT…. This is an automated editorial draft based on the abstract and requires source review before publication.
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