Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.

This in vitro or cellular study examined Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. The abstract describes Fibroblast model. The abstract reports: To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.

This uncontrolled human study examined Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: We found that the levels of lactic acid, pyruvate and lactate dehydrogenase were significantly lower in the blood of DMMHR group than DMMH group. This is an automated editorial draft based on the abstract and requires source review before publication.

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Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice.

This animal study examined Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. The abstract describes Mouse model. The abstract reports: The present data suggest that ERW may protects beta-cell damage and would be useful for antidiabetic agent. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model.

This animal study examined Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. The abstract describes Rat model; sample size 8; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 8 weeks. The abstract reports: Hydrogen-rich saline effectively improved erectile function in a streptozotocin induced diabetic rat model of erectile dysfunction. This is an automated editorial draft based on the abstract and requires source review before publication.

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Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice.

This animal study examined Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. The abstract describes Mouse model. The abstract reports: Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic beta-cell dysfunction found in diabetes. This is an automated editorial draft based on the abstract and requires source review before publication.

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Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress.

This animal study examined Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. The abstract describes Rat model; hydrogen delivered as injected or infused hydrogen. The abstract reports: Hydrogen saturated saline may improve the insulin resistance and alleviate the symptoms of diabetes mellitus by reducing the oxidative stress and enhancing the anti-oxidant…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice.

This animal study examined Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen water. The abstract reports: Hydrogen-rich water intake significantly improved RBF dysregulation in diabetic mice. Hydrogen may improve impaired neurovascular coupling function in diabetic mice by suppressing gliosis and…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin.

This animal study examined Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The results indicate that the systemic delivery of hydrogen saline water, which is safe and well tolerated, preserves bone volume and decreases fracture risks…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.

This animal study examined Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Drinking HW significantly reduced neointima formation after vein grafting in rats. Drinking HW may have therapeutic value as a novel therapy for intimal hyperplasia…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats.

This animal study examined Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Nissl staining and electron microscopy results indicated that HRW intake had protective effects on the CPF-induced damage of hippocampal neurons and neuronal mitochondria. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of hydrogen-rich water on aging periodontal tissues in rats.

This animal study examined Effects of hydrogen-rich water on aging periodontal tissues in rats. The abstract describes Rat model; sample size 12; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.

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Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice.

This uncontrolled human study examined Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: However, H₂ supplementation does not result in detectable changes in striatal H₂ levels, indicating an indirect effect. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen‐Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti‐Inflammatory Effects in an Acute Ischemia‐Reperfusion Injury Mouse Model

This animal study examined Hydrogen‐Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti‐Inflammatory Effects in an Acute Ischemia‐Reperfusion Injury Mouse Model. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Hydrogen treatment could potentially be a future therapeutic strategy for ischemia and its derived neurodegenerative diseases by improving cognitive abilities and inducing antioxidative and…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.

This uncontrolled human study examined Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice. The abstract describes Human participants. The abstract reports: We found that 2% H inhalation can reduce pro-inflammatory factors, alleviate DNMT1, DNMT3a but not DNMT3b expression, make hypomethylation of BDNF promoter IV at…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status.

This animal study examined Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status. The abstract describes Rat model; hydrogen delivered as hydrogen water and hydrogen inhalation. The abstract reports: Pathway enrichment analysis showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. This is an automated editorial draft based on the abstract and requires source review before publication.

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