Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights.
This animal study examined Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 60 days. The abstract reports: Histological results revealed that HRW reduced neuronal swelling, degeneration, and loss and enhanced dendritic spine density and neurogenesis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes
This in vitro or cellular study examined Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes. The abstract describes HaCaT keratinocyte model. The abstract reports: Our results showed that H exerted cytoprotective effects against stress induced by HO, t-BuOOH, and glyoxal. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePositive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease
This animal study examined Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease. The abstract describes Rat model. The abstract reports: In conclusion, the PD animal model showed increased intestinal permeability together with hepatic inflammation correlated with altered gut microbiota. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRandomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study
Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H) functions as a highly effective antioxidant in animal models of PD. A placebo-controlled, randomized, double-blind, parallel-group clinical pilot study was conducted to assess the efficacy of hydrogen gas inhalation in Japanese patients with PD on treatment with levodopa.
Read MoreTherapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease
This in vitro or cellular study examined Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease. The abstract describes Cell culture / in vitro model. The abstract reports: Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics.
Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score of Parkinson's disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. Changes in the total UPDRS scores from baseline to the 8(th), 24(th), 48(th), and 72(nd) weeks, and after the 8(th) week, will be evaluated.
Read MorePilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind placebo‐controlled trial
Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson's features in model animals.
Read MoreInhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease.
Hyposmia is one of the earliest and the most common symptoms in Parkinson's disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinary 8-hydroxy-2'-deoxyguanine (8-OHdG) levels by a randomized, double-blinded, placebo-controlled, crossover trial with an 8-week washout period in 20 patients with PD.
Read MoreHydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
This animal study examined Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. The abstract describes Mouse model. The abstract reports: The concentration-dependency of H(2) showed that H(2) as low as 0.08 ppm had almost the same effect as saturated H(2) water (1.5 ppm). This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRealizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease.
This case report or case series examined Realizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation; reported duration 35 years. The abstract reports: Fox Foundation has been funding research on Parkinson's disease for 35 years, but has yet to find a cure. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRole and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases.
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by a pathology that includes the aggregation of alpha-synuclein (α-syn), oxidative stress, and neuroinflammation. While existing treatments can alleviate motor symptoms, they have limited efficacy in slowing disease progression and improving non-motor symptoms. In recent years, molecular hydrogen has been recognized for its potential neuroprotective effects, attributed to its selective antioxidant and anti-inflammatory properties.
Read MoreEffects of hydrogen gas inhalation on L-DOPA-induced dyskinesia.
This uncontrolled human study examined Effects of hydrogen gas inhalation on L-DOPA-induced dyskinesia. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study.
This uncontrolled human study examined Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study. The abstract describes Human participants; sample size 18; hydrogen delivered as hydrogen water. The abstract reports: This novel, proof-of-concept study demonstrated that PBM+H2 therapy is safe and reduces disease severity. A larger-scaled clinical trial is warranted to completely investigate the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation.
This animal study examined Hydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation. The abstract describes Mouse model; hydrogen delivered as hydrogen water and topical hydrogen. The abstract reports: Hydrogen gas (H) has been demonstrated that has antioxidative, anti-inflammatory, and antifibrosis effects. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEmerging mechanisms and novel applications of hydrogen gas therapy.
Clinical and pre-clinical studies have reported a broad range of applications for hydrogen gas therapy. Classically, conventional antioxidant therapy is limited because it neutralizes both the detrimental and protective effects of reactive oxygen species. As a weak reducing agent, hydrogen gas avoids this paradox by reacting with strong oxidants while leaving other beneficial oxidants reactive.
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