Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture.
Six commercial divers were evaluated during an open-sea dive to 500 meters while breathing a mixture containing 49% hydrogen together with helium and oxygen. The study reported moderate high-pressure nervous-system symptoms and detectable narcotic effects of hydrogen while the divers completed the operational dive. It is included as related safety and physiology background because this extreme hyperbaric exposure was not a therapeutic hydrogen treatment and cannot be generalized to clinical use.
Read MoreDesign of a Functional Eye Dressing for Treatment of the Vitreous Floater.
This study evaluated a functional eye dressing designed to deliver both molecular hydrogen and oxygen around the eye. In uncontrolled clinical observations involving 28 patients, the authors reported improvement in sensory-floater symptoms. Because the dressing delivered two gases and the study did not include a controlled comparator, the contribution of molecular hydrogen cannot be isolated.
Read MoreRealizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease.
This human publication evaluated hydrogen gas in In the midbrain of Parkinson's disease patients, hydroxyl radicals generated by the Fenton reaction cause a chain reaction of oxidation of dopamine, but hydrogen entering the midbrain can convert the.
Read MoreElectrolytic hydrogen-generating bottle supplies drinking water with free/combined chlorine and ozone repressed within safety standard under hydrogen-rich conditions.
Thirty minutes of electrolysis increased dissolved hydrogen while measured chlorine compounds remained near the tap-water level in the tested bottle system. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreHydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.
HW-bathing significantly improved wrinkle in four subjects on the back of neck on 90th day as compared to 0 day. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreElectrolytic hydrogen-generating bottle supplies drinking water with free/combined chlorine and ozone repressed within safety standard under hydrogen-rich conditions.
Thirty minutes of electrolysis increased dissolved hydrogen while measured chlorine compounds remained near the tap-water level in the tested bottle system. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreDifferent Waters for Different Performances: Can We Imagine Sport-Related Natural Mineral Spring Waters?
This study examined Different Waters for Different Performances: Can We Imagine Sport-Related Natural Mineral Spring Waters?. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe Role of Mast Cells in Stroke.
Mast cells (MCs) are densely granulated perivascular resident cells of hematopoietic origin. Through the release of preformed mediators stored in their granules and newly synthesized molecules, they are able to initiate, modulate, and prolong the immune response upon activation. Their presence in the central nervous system (CNS) has been documented for more than a century.
Read MoreEffects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women.
The study evaluated 30 women with high sebum and acne and a healthy comparison group of 30 women with low sebum. After four weekly treatments using alkaline water generated by a Hebe Hydrogenium+ device, sebum decreased and moisture increased. The comparison group was not a randomized sham-treatment control, and the original report did not include a dissolved molecular-hydrogen dose.
Read MoreAnti-obesity effect of alkaline reduced water in high fat-fed obese mice.
The researchers found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreEmerging strategies for the improvement of chemotherapy in bladder cancer: Current knowledge and future perspectives.
BACKGROUND: Chemotherapy is a first-line treatment for advanced and metastatic bladder cancer, but the unsatisfactory objective response rate to this treatment yields poor 5-year patient survival. Only PD-1/PD-L1-based immune checkpoint inhibitors, FGFR3 inhibitors and antibody-drug conjugates are approved by the FDA to be used in bladder cancer, mainly for platinum-refractory or platinum-ineligible locally advanced or metastatic urothelial carcinoma. Emerging studies indicate that the combination of targeted therapy and chemotherapy shows better efficacy than targeted therapy or chemotherapy alone.
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