Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model.
This animal study examined Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model. The abstract describes Canine model; reported duration 4 hours. The abstract reports: Our results demonstrated that the H-rich preservation solution attenuated ischemia-reperfusion injury in a canine left LTx model. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis.
Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors' knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status.
Read MoreMolecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress.
This uncontrolled human study examined Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Using a BALB/cJGpt mouse model, we demonstrated that anti-Dsg 1 antibodies, but not anti-Dsg 3 antibodies, induced interstitial inflammation and fibrosis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
BACKGROUND: To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). METHODS: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydrogen/oxygen mixture or oxygen therapy.
Read MoreHydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.
This animal study examined Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 12 weeks. The abstract reports: ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.
This animal study examined Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. The abstract describes Rat model; sample size 30; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation ameliorates ventilator-induced lung injury.
This uncontrolled human study examined Hydrogen inhalation ameliorates ventilator-induced lung injury. The abstract describes Human participants; sample size 8; hydrogen delivered as hydrogen inhalation; reported duration 2 hours. The abstract reports: Inhaled hydrogen gas effectively reduced VILI-associated inflammatory responses, at both a local and systemic level, via its antioxidant, anti-inflammatory and antiapoptotic effects. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice.
This animal study examined Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: These findings demonstrated that H inhalation could inhibit CS-induced COPD development in mice, which is associated with reduced ERK1/2 and NF-κB-dependent inflammatory responses. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.
This uncontrolled human study examined Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway. The abstract describes Human participants. The abstract reports: The results indicated that 2% H gas treatment increased the survival rates, decreased the W/D weight ratio and the lung injury score, alleviated the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits.
This animal study examined Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits. The abstract describes Rabbit model; hydrogen delivered as hydrogen inhalation. The abstract reports: These results demonstrate that hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury in rabbits and that the protective effects observed may be related…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor.
This animal study examined Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: High concentrations of hydrogen could ameliorate pulmonary dysfunction, airway mucus hypersecretion, oxidation damage, and inflammation response in rats exposed to concentrated ambient PM2.5. Additionally,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas inhalation ameliorates lung injury after hemorrhagic shock and resuscitation.
This animal study examined Hydrogen gas inhalation ameliorates lung injury after hemorrhagic shock and resuscitation. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: Inhalation of 2% hydrogen gas after HSR minimized the extent of lung injury by decreasing MPO activity and reducing infiltration of inflammatory cells into…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice.
This animal study examined Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice. The abstract describes Mouse model; hydrogen delivered as injected or infused hydrogen. The abstract reports: Molecular hydrogen exhibited a protective effect on the LIR-induced ALI model. Hydrogen decreased malondialdehyde and increased superoxide dismutase activity in lung tissues. Additionally, hydrogen…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHigh concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice.
This animal study examined High concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice. The abstract describes Mouse model. The abstract reports: HCH can effectively alleviate LPS-induced ALI, which may be related to activation of Nrf2 signaling pathway and inhibition of inflammatory response and cell apoptosis…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEvaluation of the therapeutic effects of nebulized inhalation of hydrogen-rich water on primary blast lung injury in C57BL/6 mice.
This animal study examined Evaluation of the therapeutic effects of nebulized inhalation of hydrogen-rich water on primary blast lung injury in C57BL/6 mice. The abstract describes Mouse model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: The overpressure generated by blasts leads to alveolar and capillary damage, resulting in ventilation-perfusion mismatch and increased intrapulmonary shunting. This is an automated editorial draft based on the abstract and requires source review before publication.
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