A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics.
Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score of Parkinson's disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. Changes in the total UPDRS scores from baseline to the 8(th), 24(th), 48(th), and 72(nd) weeks, and after the 8(th) week, will be evaluated.
Read MoreMolecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease.
This animal study examined Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind placebo‐controlled trial
Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson's features in model animals.
Read MoreInhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease.
Hyposmia is one of the earliest and the most common symptoms in Parkinson's disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinary 8-hydroxy-2'-deoxyguanine (8-OHdG) levels by a randomized, double-blinded, placebo-controlled, crossover trial with an 8-week washout period in 20 patients with PD.
Read MoreHydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
This animal study examined Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. The abstract describes Mouse model. The abstract reports: The concentration-dependency of H(2) showed that H(2) as low as 0.08 ppm had almost the same effect as saturated H(2) water (1.5 ppm). This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRealizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease.
This case report or case series examined Realizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation; reported duration 35 years. The abstract reports: Fox Foundation has been funding research on Parkinson's disease for 35 years, but has yet to find a cure. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRole and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases.
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by a pathology that includes the aggregation of alpha-synuclein (α-syn), oxidative stress, and neuroinflammation. While existing treatments can alleviate motor symptoms, they have limited efficacy in slowing disease progression and improving non-motor symptoms. In recent years, molecular hydrogen has been recognized for its potential neuroprotective effects, attributed to its selective antioxidant and anti-inflammatory properties.
Read MoreComplexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice.
This animal study examined Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. The abstract describes Mouse model. The abstract reports: The protective effect of H water was still observed in the vagotomized mice in substantia nigra, suggesting that stimulation of vagal afferent nerves is…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreChronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats.
This uncontrolled human study examined Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline; reported duration 3 months. The abstract reports: Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study.
This uncontrolled human study examined Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study. The abstract describes Human participants; sample size 18; hydrogen delivered as hydrogen water. The abstract reports: This novel, proof-of-concept study demonstrated that PBM+H2 therapy is safe and reduces disease severity. A larger-scaled clinical trial is warranted to completely investigate the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation.
This animal study examined Hydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation. The abstract describes Mouse model; hydrogen delivered as hydrogen water and topical hydrogen. The abstract reports: Hydrogen gas (H) has been demonstrated that has antioxidative, anti-inflammatory, and antifibrosis effects. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEmerging mechanisms and novel applications of hydrogen gas therapy.
Clinical and pre-clinical studies have reported a broad range of applications for hydrogen gas therapy. Classically, conventional antioxidant therapy is limited because it neutralizes both the detrimental and protective effects of reactive oxygen species. As a weak reducing agent, hydrogen gas avoids this paradox by reacting with strong oxidants while leaving other beneficial oxidants reactive.
Read MoreHydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia.
This animal study examined Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: It was found that hydrogen-rich saline (LH group) decreased placental MDA, proteinuria, TNF-α, and IL-1β levels in the placental tissues compared with the L…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreElectrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water
This in vitro or cellular study examined Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water. The abstract describes HT1080 cell model. The abstract reports: ERW has reactive oxygen species (ROS)-scavenging activity and recent studies demonstrated that hydrogen-dissolved water exhibits ROS-scavenging activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.
This animal study examined Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis. The abstract describes Rabbit model; hydrogen delivered as injected or infused hydrogen. The abstract reports: These results suggested that molecular hydrogen prevents steroid-induced osteonecrosis in rabbits by suppressing oxidative injury, vascular injury and apoptosis. This is an automated editorial draft based on the abstract and requires source review before publication.
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