Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response.
This animal study examined Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response. The abstract describes Mouse model. The abstract reports: We found that H activated the expression of sets of genes regulated by histone H3K27 methylation status. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water affected blood alkalinity in physically active men.
This randomized controlled trial examined Hydrogen-rich water affected blood alkalinity in physically active men. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 14 days. The abstract reports: These results support the hypothesis that HRW administration is safe and may have an alkalizing effect in young physically active men. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study.
This randomized controlled trial examined Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation; reported duration 60 minutes. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.
This animal study examined Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: The results collectively indicated that hydrogen significantly attenuated CUMS-induced depressive-like behavior and monoamine neurotransmitter deficiency, as well as protected the brain from oxidative stress…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water supplementation improves metabolic profile during peripartum period in Gurcu goats and enhances the health and survival of kids.
This animal study examined Hydrogen-rich water supplementation improves metabolic profile during peripartum period in Gurcu goats and enhances the health and survival of kids. The abstract describes hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice.
This animal study examined Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice. The abstract describes Mouse model. The abstract reports: Although the underlying mechanisms of bmTBI are largely unknown, some studies suggested that bmTBI is associated with blood-brain barrier disruption, oxidative stress, and edema…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside.
Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated that H may act as an antioxidant to exert therapeutic and preventive effects on various disorders, including metabolic diseases.
Read MoreModulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen’s Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats
This animal study examined Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen’s Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats. The abstract describes Rat model. The abstract reports: Experimental results showed that a 7-day MSN intervention significantly attenuated anxiety-like behaviors while reversing the synaptic deficits induced by SPS&S in prefrontal cortical regions. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation.
This animal study examined Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: These results demonstrate that HS restored behavioral deficits after HI in neonatal mice. These beneficial effects, in part, involve promoting microglia M2 polarization and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens.
This animal study examined Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: We found that HRS administration was able to inhibit the acquisition and transfer of 0.1 and 0.5 mg/kg METH-induced behavioral sensitization to a certain extent,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life.
This randomized controlled trial examined Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 4 weeks. The abstract reports: In healthy individuals, aging, job stress, and cognitive load over several hours also induce increases in oxidative stress, suggesting that preventing the accumulation of…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of hydrogen-rich water on depressive-like behavior in mice.
This uncontrolled human study examined Effects of hydrogen-rich water on depressive-like behavior in mice. The abstract describes Human participants; hydrogen delivered as hydrogen water and hydrogen-rich saline. The abstract reports: Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAdministration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model
This animal study examined Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model. The abstract describes Mouse model. The abstract reports: We have previously demonstrated in the MIA mouse model that maternal administration of H attenuates oxidative damage and neuroinflammation, including induced pro-inflammatory cytokines and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring.
This animal study examined Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring. The abstract describes Mouse model; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAdditive effect of clove essential oil combined with hydrogen inhalation improves psychological harm caused by lipopolysaccharide in mice.
This animal study examined Additive effect of clove essential oil combined with hydrogen inhalation improves psychological harm caused by lipopolysaccharide in mice. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: Our results suggest that a combination of CEO and H has the potential to treat psychological disorders or neuropsychiatric disorders. This is an automated editorial draft based on the abstract and requires source review before publication.
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