Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways.
This animal study examined Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways. The abstract describes Rat model. The abstract reports: Rats exposed 2 h daily to H either by drinking HRW (H dissolved in HO) or by breathing 4% H gas showed reduced lipogenesis and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
This animal study examined A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreBiological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial.
This randomized controlled trial examined Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial. The abstract describes Human participants; sample size 30; hydrogen delivered as hydrogen water. The abstract reports: The favorable trends in this study in conjunction with previous animal and clinical findings suggest that HRW may serve as an important adjuvant therapy…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats
This animal study examined A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats. The abstract describes Rat model; sample size 32. The abstract reports: We found that CCl can induce significant steatosis in hepatocytes. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling.
This in vitro or cellular study examined Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTranslational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen.
This uncontrolled human study examined Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen. The abstract describes Human participants; reported duration 3 weeks. The abstract reports: Also, results of immunostaining analysis revealed increased vimentin and apoptotic cells in the membrane of the PD group, indicating that H2 may play a…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRenal replacement strategies: dual benefits of hydrogen gas inhalation and hydrogen-enriched dialysate.
This uncontrolled human study examined Renal replacement strategies: dual benefits of hydrogen gas inhalation and hydrogen-enriched dialysate. The abstract describes Human participants; sample size 11; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: Emerging clinical evidence suggests that combining H2 gas inhalation and RRT using H2-enriched dialysate may enhance the management of oxidative stress and inflammation in…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging.
This animal study examined Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. The abstract describes Rat model; hydrogen delivered as hydrogen water and injected or infused hydrogen; reported duration 7 days. The abstract reports: Our findings suggested reduced oxygen utility, mainly in the cortex, in gentamicin-induced nephrotoxicity and an ameliorative effect of hydrogen-rich water against GIN. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreReduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.
This uncontrolled human study examined Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. The abstract describes Human participants; reported duration 1 month. The abstract reports: This study demonstrates that hemodialysis with ERW administration may efficiently increase the H2O2- and HOCl-dependent antioxidant defense and reduce H2O2- and HOCl-induced oxidative stress. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreDissolved molecular hydrogen (H) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity.
Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD discontinuation. Recent studies have revealed the unique biological action of molecular hydrogen (H) as an anti-oxidant, which ameliorates tissue injury.
Read MoreMolecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report
Hydrogen therapy has demonstrated potential as an antioxidant and anti-inflammatory intervention, particularly in the management of chronic diseases such as chronic kidney disease (CKD) and autoimmune conditions. This case report presents the possible therapeutic benefits of molecular hydrogen capsule treatment in enhancing renal function and alleviating chronic fatigue in an elderly female with coronary artery disease (CAD), type 2 diabetes mellitus (DM) complicated by nephropathy, and systemic lupus erythematosus (SLE). The aim of this study was to investigate the efficacy of adjunctive hydrogen therapy in an elderly patient with multiple…
Read MoreTherapeutic effect of hydrogen and its mechanisms in kidney disease treatment.
Hydrogen is a simple, colorless, and biologically active small molecule gas that can react with reactive oxygen species. Recent research suggests that hydrogen possesses several biological effects, including antioxidant, anti-inflammatory, and anti-apoptotic effects, while exhibiting an extremely high level of safety. Hydrogen application has shown promise in treating a range of acute and chronic diseases, both benign and malignant.
Read MoreHydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model.
This animal study examined Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen-rich saline against renal ischemia-reperfusion injury by increased expression of heme oxygenase-1 in aged rats.
This animal study examined Protective effects of hydrogen-rich saline against renal ischemia-reperfusion injury by increased expression of heme oxygenase-1 in aged rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HRS improves the renal response to I/R in aged rats, possibly by reducing oxidative stress and upregulating HO-1 gene expression. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePrevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
This animal study examined Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model. The abstract describes Porcine model. The abstract reports: A few cases showed chronic rejection reaction; however, most were found to be free of chronic rejection such as graft tissue fibrosis or renal…. This is an automated editorial draft based on the abstract and requires source review before publication.
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