Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner.

This animal study examined Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner. The abstract describes Mouse model. The abstract reports: Finally, we found that H improved survival rates and brain dysfunction and decreased inflammatory cytokines. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy.

This in vitro or cellular study examined Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen water; reported duration 10 days. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress.

This uncontrolled human study examined Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress. The abstract describes Human participants; reported duration 5 weeks. The abstract reports: Our results showed that H treatment improved the CIH-induced spatial learning and memory impairments. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

This animal study examined Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases. The abstract describes hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment.

This animal study examined Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen water and injected or infused hydrogen. The abstract reports: We found that the molecular hydrogen delivered by HRW consumption significantly inhibited the METH-induced spatial learning impairment and memory loss evidenced in the Barnes…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress.

This animal study examined Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress. The abstract describes Rabbit model. The abstract reports: Results show that irrigation of the damaged eyes with H solution immediately after the injury and then within next five days renewed corneal transparency…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals.

This narrative review examined Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals. The abstract describes Published literature review. The abstract reports: There is a growing body of evidence based on the results of animal experiments and clinical observations that H(2) may represent an effective antioxidant…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen inhalation therapy may ameliorate amyotrophic lateral sclerosis.

This uncontrolled human study examined Hydrogen inhalation therapy may ameliorate amyotrophic lateral sclerosis. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, a neurodegenerative disorder characterized by sporadic and progressive degenerative loss of cell bodies of both…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation.

This uncontrolled human study examined Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Sepsis is associated with numerous physiological and biochemical abnormalities that result in a life-threatening condition. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation.

This animal study examined Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation. The abstract describes Mouse model. The abstract reports: The protective effect of H on cognitive dysfunction induced by SAE may be achieved by inhibiting tau phosphorylation, which is perhaps related with the…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity.

This narrative review examined Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity. The abstract describes Published literature review. The abstract reports: Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective Mechanism and Clinical Application of Hydrogen in Myocardial Ischemia-reperfusion Injury.

This uncontrolled human study examined Protective Mechanism and Clinical Application of Hydrogen in Myocardial Ischemia-reperfusion Injury. The abstract describes Human participants. The abstract reports: Ischemic injury is mainly caused by anaerobic cell death and reperfusion which results in a wide range of inflammatory responses. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway.

This animal study examined Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The results confirmed the protection of HRS in LPS-induced ALI by regulating apoptosis through inhibiting the mTOR/TFEB signaling pathway. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy.

This animal study examined Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: The results demonstrated that treatment with hydrogen improved the myocardial infarction size of hearts, cardiac function, apoptosis and cytokine release following MI/R in rats. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.

This animal study examined Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: These results showed that hydrogen-rich saline was able to attenuate FBS-induced VSMC proliferation and neointimal hyperplasia by inhibiting ROS production and inactivating the Ras-ERK1/2-MEK1/2…. This is an automated editorial draft based on the abstract and requires source review before publication.

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