Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.
The researchers observed a significant increase in the concentration of H₂ in the placenta after the oral administration of hydrogen-saturated water to the mothers, with less placental oxidative damage after IR in the presence of H₂. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreFructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid decreases maternal and female fetal oxidative stress by increasing intestinal microbe-derived hydrogen gas.
In mice, hydrogen gas concentrations in maternal livers and whole fetuses in EFA-FOS were significantly higher than those in CONT and EFA, respectively (P <.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreThe effects of hydrogen-rich water on male fertility and spermatogenesis
This study examined The effects of hydrogen-rich water on male fertility and spermatogenesis. The abstract describes hydrogen delivered as hydrogen water. The abstract reports: The results highlight the importance of more mechanistic and clinical investigations to clarify in detail the therapeutic potential of HRW in the management of…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats.
In rats, the histopathological analysis showed a reduction in the number of cysts in the PCOS + H₂ group compared with the PCOS group (P < 0.0001). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreThe Effects of Medium-Term Intake of Hydrogen-Rich Water on Sperm Quality Biomarkers in Normospermic and Oligospermic Men: A Randomized Controlled Pilot Trial
However, sperm count increased by over 20 million in two of the three oligospermic men (66.7%) receiving hydrogen-rich water, while no oligospermic men in the placebo group increased sperm concentration to euspermic levels, and live cells increased by 3.8%, respectively. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreHydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress.
In female Sprague Dawley rats, hydrogen-rich saline attenuated the FSH release, elevated the level of E2, improved the development of follicles, and reduced the damage to the ovarian cortex at T1, T2 and T3 in the OI + H₂ rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreStimulation of human damaged sperm motility with hydrogen molecule.
In a laboratory model, H₂ treatment significantly improved the rate of forward motility, whereas treatment with nitrogen gas did not. The authors concluded that the results illustrated that H₂ treatment stimulates low sperm motility. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreHydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.
This narrative review examined the available molecular-hydrogen literature. The lightest and diffusible gas molecule hydrogen (H₂) has been shown to improve erectile dysfunction (ED), testis injuries, sperm motility in male, preserve ovarian function, protect against uterine inflammation, preeclampsia, and breast cancer in female. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read More[Effect of hydrogen-rich water on the CD34 expression in lesion boundary brain tissue of rats with traumatic brain injury].
In rats, the edema area in TBI+HW group was slightly smaller than that of TBI group, and the surrounding edema was slightly reduced. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read More[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].
In rats, the mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-△△Ct):5.40±0.21 vs.7.50±0.26, 24-hour AQP1 protein (gray value): 1.246±0.137 vs.1.986±0.110, both P < 0.05]. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read More[Hydrogen rich water attenuates pregnancy gingivitis induced by ligation in SD rats].
In rats, compared with the model group, the inflammatory response of pregnancy gingivitis in HW group was significantly suppressed along with decreased NFκB and TNF-α. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
Read More[Effect of hydrogen-rich water on the chondriosome damage and cytokines in brain tissue of rats with traumatic brain injury].
In rats, nSS scores in TBI and TBI+HW groups showed a decreased tendency with time prolongation after TBI. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read More[Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury].
In rats, hydrogen rich water can up-regulate the expression of Nrf2, and reduce oxidative damage of traumatic brain injury in rats. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreKRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer.
In an animal model, kRAS, YWHAE, SP1 and MSRA might be regarded as focused biomarkers to assess the prognosis of EC. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreProtection by hydrogen against gamma ray-induced testicular damage in rats.
This publication is an erratum or correction associated with a molecular-hydrogen article. It does not report a new standalone experiment.
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