Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
Yunhai Chuai, Jianliang Shen, Liren Qian, Yicun Wang, Yuecheng Huang, Fu Gao, Jianguo Cui, Jin Ni, Luqian Zhao, Shulin Liu, Xuejun Sun, Bailong Li, Jianming Cai · Medical science monitor : international medical journal of experimental and clinical research · 2012
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, this study demonstrates that treating mice with H₂ before ionizing radiation (IR) can increase the spermatid head count and protect seminiferous epithelium from IR. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Endogenous hematopoietic spleen colony formation (endoCFUs), bone marrow nucleated cells (BMNC) and peripheral blood (PB) leukocytes were used to evaluate hemopoiesis.
How Molecular Hydrogen Was Used
The aim of this study was to investigate whether H₂ is able to protect spermatogenesis and hematopoiesis from radiation-induced injuries. MATERIAL/METHODS: H₂ was dissolved in physiological saline using an apparatus produced by the authors' department. -60Co-gamma rays in the irradiation centre were used for irradiation.
What the Researchers Found
This study demonstrates that treating mice with H₂ before ionizing radiation (IR) can increase the spermatid head count and protect seminiferous epithelium from IR. This study also demonstrates that H₂ could significantly increase the number of endoCFUs, BMNC and PB leukocyte.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included recent studies show that molecular hydrogen (dihydrogen, H₂) has potential as an effective and safe radioprotective agent through reducing oxidative stress.
Authors’ Conclusion
The authors concluded that this study suggests that hydrogen-rich saline could partially protect spermatogenesis and hematopoiesis in irradiated mice.