1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats.
Tsunehisa Sato, Soichiro Mimuro, Takasumi Katoh, Tadayoshi Kurita, Sang Kien Truong, Kensuke Kobayashi, Hiroshi Makino, Matsuyuki Doi, Yoshiki Nakajima · Journal of anesthesia · 2020
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Independent study record
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H2HUBB TAKEAWAY
In Sprague-Dawley rats, inhalation of 1.2% H₂ gas protected the endothelial glycocalyx and prolonged survival time during hemorrhagic shock. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The researchers hypothesized that H₂ protected the endothelial glycocalyx during hemorrhagic shock and prolonged survival time.
How Molecular Hydrogen Was Used
The animals were randomly assigned to 5 groups: room air with no shock, 1.2% H₂ with no shock, room air with shock (Control-S), 1.2% H₂ with shock (H21.2%-S), and 3.0% H₂ with shock (H23.0%-S).
What the Researchers Found
Inhalation of 1.2% H₂ gas protected the endothelial glycocalyx and prolonged survival time during hemorrhagic shock.
Authors’ Conclusion
The authors concluded that inhalation of 1.2% H₂ gas protected the endothelial glycocalyx and prolonged survival time during hemorrhagic shock. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.