Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model.
Kenji Imai, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Takafumi Ushida, Akira Iwase, Taku Nagai, Shinya Toyokuni, Akio Suzumura, Fumitaka Kikkawa · Scientific reports · 2018
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Independent study record
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H2HUBB TAKEAWAY
In Moreover, the researchers evaluated the effect of H₂ on LPS-induced astrocytic activation, both in vivo and in vitro, the number of activated astrocytes with hypertrophic morphology was increased in LPS-exposed offspring, but decreased in the offspring of H₂-administered dams. The authors concluded that these findings indicate that maternal H₂ administration exerts neuroprotective effects and ameliorates MIA-induced neurodevelopmental deficits of offspring later in life. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
Laboratory Model
The researchers evaluated the effect of H₂ on LPS-induced astrocytic activation, both in vivo and in vitro.
How Molecular Hydrogen Was Used
The researchers evaluated the effect of H₂ on LPS-induced astrocytic activation, both in vivo and in vitro.
What Molecular Hydrogen Changed
The number of activated astrocytes with hypertrophic morphology was increased in LPS-exposed offspring, but decreased in the offspring of H₂-administered dams.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.