Hydrogen Research Study
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Laboratory or cellular evidenceLaboratory StudyOther or not reported

Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model.

Kenji Imai, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Takafumi Ushida, Akira Iwase, Taku Nagai, Shinya Toyokuni, Akio Suzumura, Fumitaka Kikkawa · Scientific reports · 2018

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Independent study record

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H2HUBB Research Library branded molecular hydrogen research image
Primary topic Molecular Hydrogen Overview
Evidence type Laboratory or cellular evidence
Publication type Laboratory Study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

In Moreover, the researchers evaluated the effect of H₂ on LPS-induced astrocytic activation, both in vivo and in vitro, the number of activated astrocytes with hypertrophic morphology was increased in LPS-exposed offspring, but decreased in the offspring of H₂-administered dams. The authors concluded that these findings indicate that maternal H₂ administration exerts neuroprotective effects and ameliorates MIA-induced neurodevelopmental deficits of offspring later in life. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.

What the Researchers Tested

In vitro cell-culture laboratory experiment.

Laboratory Model

The researchers evaluated the effect of H₂ on LPS-induced astrocytic activation, both in vivo and in vitro.

How Molecular Hydrogen Was Used

The researchers evaluated the effect of H₂ on LPS-induced astrocytic activation, both in vivo and in vitro.

What Molecular Hydrogen Changed

The number of activated astrocytes with hypertrophic morphology was increased in LPS-exposed offspring, but decreased in the offspring of H₂-administered dams.

Authors’ Conclusion

These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.