Hydrogen: a review of the effects and underlying mechanisms in oral diseases
Liu, Zhaogang, Li, Yuexiu, Liu, Ying, Zhao, Zhentao, Zhang, Li, Ge, Chenxin, Gao, Jing · Frontiers in Pharmacology · 2026
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Independent study record
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The review reports that This review summarizes the primary strategies for and research on hydrogen therapy, as well as the application of hydrogen in oral diseases such as dental caries, periodontitis, peri-implantitis…
What the Researchers Studied
Source-reported study description: Oral diseases can affect the quality of life of patients and cause secondary systemic diseases, thereby harming systemic health.
Source-reported study description: Hydrogen has been shown to exhibit anti-oxidant stress, anti-inflammatory and anti-apoptosis and other effects, indicating its therapeutic significance for many kinds of diseases.
What the Study Found
The authors reported: Hydrogen administered through different methods can effectively reduce plaque biofilm formation, resist oxidative stress, inhibit the inflammatory response, and promote tissue repair and regeneration.
What the Findings Mean
The authors concluded/reported: This review summarizes the primary strategies for and research on hydrogen therapy, as well as the application of hydrogen in oral diseases such as dental caries, periodontitis, peri-implantitis…
Study Details
Publication type: narrative_review
Evidence source level: B_ABSTRACT
Original scholarly source: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1902221/full