An intelligent inflammation-responsive hydrogel for localized and sustained co-delivery of hydrogen and magnesium ions to regenerate degenerative intervertebral discs
Dan Li, Wanrong Yang, Jishi Jiang, Yifei Li, Wei Jiao, Hongliang Wang, Donglin Fu, Yunpeng Wan, Haiyang Yu, Yongjin Sun · Materials & Design · 2026
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Independent study record
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In this laboratory study, the authors report that This photocrosslinkable hydrogel enables minimally invasive injection and in situ gelation, forming a stable implant that undergoes matrix metalloproteinase (MMP)-triggered degradation within the degenerative disc microenvironment, thereby enabling…
What the Researchers Studied
Source-reported study description: Intervertebral disc degeneration (IVDD), a major cause of lower back pain, is characterized by oxidative stress, inflammation, and cellular senescence.
Source-reported study description: Hydrogen therapy shows promise in mitigating these pathological processes, however, its clinical translation is hindered by poor bioavailability and rapid clearance.
What the Study Found
The authors reported: Here, we developed an innovative, inflammation-responsive magnesium hydride (MgH2)-loaded GelMA-PLGA-MMP hydrogel system (MgH2@GPMgel) for the sustained and localized delivery of hydrogen and magnesium ions to treat IVDD.
What the Findings Mean
The authors concluded/reported: This photocrosslinkable hydrogel enables minimally invasive injection and in situ gelation, forming a stable implant that undergoes matrix metalloproteinase (MMP)-triggered degradation within the degenerative disc microenvironment, thereby enabling…
Study Details
Publication type: laboratory_study
Evidence source level: B_ABSTRACT
Original scholarly source: https://doi.org/10.1016/j.matdes.2026.116921