Anti‐Inflammatory and Bacteriostatic Effects of Hydrogen‐Rich Water on Rats With Periodontitis
Yang Bai, Lisheng Zhao, Lin Wang, Yanbo Shan, Wei Zhang, Ning Wen · Journal of Food Biochemistry · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, the contents of proinflammatory factors tumor necrosis factor alpha (TNF‐ α ), interleukin‐1 beta (IL‐1 β ), and interleukin‐6 (IL‐6) in PB serum and gingival crevicular fluid (GCF) of rats in model group were significantly increased, and HRW intake reversed these and promoted the level of anti‐inflammatory factor interleukin‐10 (IL‐10). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in rats. The contents of proinflammatory factors tumor necrosis factor alpha (TNF‐ α ), interleukin‐1 beta (IL‐1 β ), and interleukin‐6 (IL‐6) in PB serum and gingival crevicular fluid (GCF) of rats in model group were significantly increased, and HRW intake reversed these and promoted the level of anti‐inflammatory factor interleukin‐10 (IL‐10).
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
The contents of proinflammatory factors tumor necrosis factor alpha (TNF‐ α ), interleukin‐1 beta (IL‐1 β ), and interleukin‐6 (IL‐6) in PB serum and gingival crevicular fluid (GCF) of rats in model group were significantly increased, and HRW intake reversed these and promoted the level of anti‐inflammatory factor interleukin‐10 (IL‐10). The authors concluded that HRW can effectively inhibit the growth of periodontal pathogens and reduce inflammation and may be used to prevent or ameliorate periodontitis.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://onlinelibrary.wiley.com/doi/pdf/10.1155/jfbc/5917799.