Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress. Molecules 2019, 24, 2076.) How to cite this book chapter: Tyler W LeBaron, Branislav
welcome · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a rat model of myocardial I/R injury, inhalation of 2% H₂ at the onset of ischemia, and for 60 min after reperfusion, reduced infarct size, lowered LV-end-diastolic pressure, attenuated pathological remodeling, and improved cardiac function 30 days Prime Archives in Molecular Biology 27 www.videleaf.com after the myocardial I/R injury [104]. For example, in irradiated animals, the lipid peroxidation marker MDA was significantly increased in the small intestine, but was not similarly elevated in the hydrogen-water group [165]. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. In a rat model of myocardial I/R injury, inhalation of 2% H₂ at the onset of ischemia, and for 60 min after reperfusion, reduced infarct size, lowered LV-end-diastolic pressure, attenuated pathological remodeling, and improved cardiac function 30 days Prime Archives in Molecular Biology 27 www.videleaf.com after the myocardial I/R injury [104].
What the Researchers Studied
The study used a preclinical animal experiment. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 1% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 1% source-reported H₂ gas concentration; reported treatment duration: 60 min. In a rat model of myocardial I/R injury, inhalation of 2% H₂ at the onset of ischemia, and for 60 min after reperfusion, reduced infarct size, lowered LV-end-diastolic pressure, attenuated pathological remodeling, and improved cardiac function 30 days Prime Archives in Molecular Biology 27 www.videleaf.com after the myocardial I/R injury [104]. The authors concluded that taken together, these results suggest that both inhalation of H₂ gas and oral administration of H₂ water may protect against inflammation and oxidative-stress related cancer drugs, and thus improve the antitumor effect in the clinical management of cancer [165].
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The reported sample size was 49. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 1% source-reported H₂ gas concentration. The reported treatment duration was 60 min.
Limitations and Safety
Safety information: Indeed one promising clinical study demonstrated that Prime Archives in Molecular Biology 31 www.videleaf.com H₂ inhalation (1.3% H₂) during primary percutaneous coronary intervention (PCI) is a feasible and safe treatment option for patients with ST-elevated myocardial infarction, and may prevent adverse left ventricular remodeling after primary PCI [197].
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://videleaf.com/wp-content/uploads/2020/03/A-New-Approach-for-the-Prevention-and-Treatment-of-Cardiovascular-Disorders-Molecular-Hydrogen-Significantly-Reduces-the-Effects-of-Oxidative-Stress.pdf.