Brain creatine metabolism modulated by hydrogen-enriched water
Dragana Zanini, Nikola Todorovic, Korovljev Darinka, Stajer Valdemar, Bogdan Andjelic, Marijana Ranisavljev, Jovan Kuzmanovic, Sergej M. Ostojic · Journal of the International Society of Sports Nutrition · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 8 healthy participants (4 women), compared to the placebo group, HRW supplementation was associated with increased creatine levels in the right parietal white matter (from 6.0 ± 1.1 to 6.3 ± 1.6 ppm) and decreased creatine levels in the left parietal-mesial gray matter (from 4.4 ± 2.3 to 4.2 ± 2.3 ppm) (P < 0.05). These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 8 healthy participants (4 women). Compared to the placebo group, HRW supplementation was associated with increased creatine levels in the right parietal white matter (from 6.0 ± 1.1 to 6.3 ± 1.6 ppm) and decreased creatine levels in the left parietal-mesial gray matter (from 4.4 ± 2.3 to 4.2 ± 2.3 ppm) (P < 0.05).
What the Researchers Studied
The researchers studied 8 healthy participants (4 women). The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 500 mL hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂. Compared to the placebo group, HRW supplementation was associated with increased creatine levels in the right parietal white matter (from 6.0 ± 1.1 to 6.3 ± 1.6 ppm) and decreased creatine levels in the left parietal-mesial gray matter (from 4.4 ± 2.3 to 4.2 ± 2.3 ppm) (P < 0.05). The authors concluded that to conventional creatine-enhancing supplements, hydrogen-based supplementation may modulate age-related and region-specific creatine dynamics in the brain.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 8 healthy participants (4 women). The reported sample size was 4. The study used a randomized, double-blind, placebo-controlled human clinical trial. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen exposure was 500 mL hydrogen-rich water/day; dissolved H₂ concentration was not sufficiently reported, so H2HUBB did not estimate milligrams of H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.