Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W LeBaron · Oxidative medicine and cellular longevity · 2021
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This narrative review examined the available evidence on molecular hydrogen. H₂ has been demonstrated to suppress NF-κB inflammatory signaling and induce the Nrf2/Keap1 antioxidant pathway, as well as to improve mitochondrial function and enhance cellular bioenergetics. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
The review examined combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.
Main Findings Across the Literature
The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. However, these methods have not significantly improved treatment outcomes.
H₂ Mechanisms / Biological Findings
This may partly be attributable to their inability at restoring redox and inflammatory homeostasis, for which molecular hydrogen (H₂), an emerging novel medical gas, may complement.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.