Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers.
Moto Fukai, Sodai Sakamoto, Kengo Shibata, Masato Fujiyoshi, Sunao Fujiyoshi, Hiroki Bochimoto, Takahisa Ishikawa, Shingo Shimada, Kosei Nakamura, Norio Kawamura, Tsuyoshi Shimamura, Akinobu Taketomi · Transplantation proceedings · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The protective potential of the Dsol-H₂ group was superior to that of the UW group, as evidenced by lower portal venous resistance and lactate dehydrogenase leakage, a higher oxygen consumption rate, and increased bile production. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Publication Examined
Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers.
How Molecular Hydrogen Was Addressed
The researchers previously reported the efficacy of cold storage (CS) using a heavy water-containing solution (Dsol) and post-reperfusion hydrogen gas treatment separately. The experimental groups were the immediately reperfused control group (CT), the CS with University of Wisconsin solution (UW) group, the CS with Dsol group, the CS with UW and post-reperfusion H₂ treatment group (UW-H₂), and the CS with Dsol and post-reperfusion H₂ group (Dsol-H₂). The protective potential of the Dsol-H₂ group was superior to that of the UW group, as evidenced by lower portal venous resistance and lactate dehydrogenase leakage, a higher oxygen consumption rate, and increased bile production.
What the Publication Reported
The protective potential of the Dsol-H₂ group was superior to that of the UW group, as evidenced by lower portal venous resistance and lactate dehydrogenase leakage, a higher oxygen consumption rate, and increased bile production.
Authors’ Conclusion
The authors concluded that in conclusion, combination therapy with Dsol during CS and hydrogen gas after reperfusion additively protects against graft injury.