Dual-wavelength-responsive GMMC-Pdots-Ag hydrogel for spatiotemporally controlled photothermal and hydrogen therapy of infected liver and skin defects.
Ze Zhang, Zhipeng Huang, Chenghan Zhang, Weiping Qin, Chenlong Zhong, Shengyan Yin, Qingmin Chen, Xinyue Deng · Colloids and surfaces. B, Biointerfaces · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This publication examined molecular hydrogen using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. In vivo studies using skin and liver infection models demonstrated accelerated wound closure, reduced inflammatory infiltration, enhanced angiogenesis, and improved tissue regeneration.
What Effects Did Molecular Hydrogen Have?
The hydrogel is based on a dynamic double-network architecture composed of gelatin methacryloyl (GelMA), O-carboxymethyl chitosan (O-CMC), and 4-arm poly(ethylene glycol) benzaldehyde (4-arm-PEG-DF), co-loaded with PtOEP-doped T2-DPPT@NH2 polymer dots (Pdots) and L-histidine-stabilized silver nanoparticles (His-Ag NPs). The generated H₂ selectively scavenges cytotoxic reactive oxygen species (ROS), especially ·OH and •O₂-, and inhibits M1 macrophage polarization through modulation of the NOD-associated MAPK and AP-1 signaling pathways. In vivo studies using skin and liver infection models demonstrated accelerated wound closure, reduced inflammatory infiltration, enhanced angiogenesis, and improved tissue regeneration.
Why These Findings Matter
These findings add evidence supporting molecular hydrogen's therapeutic potential within the biological process and outcomes directly measured in this publication and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
H2HUBB classifies this publication as other research and interprets only the outcomes directly supported by the source record.
Technical Study Details
H2HUBB classifies this publication as other research with other supported evidence.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.
What the Researchers Studied
The available source identifies this publication as other research. A more specific population or model was not separately reported in the source text available to H2HUBB.