Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model.
Yinmon Htun, Shinji Nakamura, Yasuhiro Nakao, Tsutomu Mitsuie, Kenichi Ohta, Makoto Arioka, Takayuki Yokota, Eri Inoue, Kota Inoue, Toi Tsuchiya, Kosuke Koyano, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Takashi Kusaka · Scientific reports · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, the NT, H₂, and H₂ -TH groups showed a significant reduction in HR at 0 h (end of insult), whereas the TH group showed a nonsignificant reduction in HR compared with baseline. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas was evaluated in this publication and summarizes the source-grounded findings below. The NT, H₂, and H₂ -TH groups showed a significant reduction in HR at 0 h (end of insult), whereas the TH group showed a nonsignificant reduction in HR compared with baseline.
What the Researchers Studied
The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2.7% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2.7% source-reported H₂ gas concentration. The NT, H₂, and H₂ -TH groups showed a significant reduction in HR at 0 h (end of insult), whereas the TH group showed a nonsignificant reduction in HR compared with baseline.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 2.7% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.