Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model.
Yinmon Htun, Shinji Nakamura, Yasuhiro Nakao, Tsutomu Mitsuie, Kenichi Ohta, Makoto Arioka, Takayuki Yokota, Eri Inoue, Kota Inoue, Toi Tsuchiya, Kosuke Koyano, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Takashi Kusaka · Scientific reports · 2023
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In the authors' previous studies, hydrogen gas (H₂) improved the neurological outcome of HIE and ameliorated the cell death. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
Laboratory Model
The important determinants of its pathophysiology are neural cells and vascular components.
How Molecular Hydrogen Was Used
In the authors' previous studies, hydrogen gas (H₂) improved the neurological outcome of HIE and ameliorated the cell death. In this study, the researchers used albumin immunohistochemistry to assess if H₂ inhalation effectively reduced the cerebral vascular leakage. After the insult, the piglets were grouped into normothermia (NT), H₂ ventilation (H₂), therapeutic hypothermia (TH), and H₂ combined with TH (H₂-TH) groups.
What Molecular Hydrogen Changed
In the authors' previous studies, hydrogen gas (H₂) improved the neurological outcome of HIE and ameliorated the cell death.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.