Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.
Kazufumi Nagata, Naomi Nakashima-Kamimura, Toshio Mikami, Ikuroh Ohsawa, Shigeo Ohta · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided. These results are preclinical and add to understanding of how molecular hydrogen affects the condition studied. Further human research is needed to determine its clinical relevance.
How Molecular Hydrogen Was Used
Consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided. The consumption of hydrogen water ameliorated the reduced proliferation although the mechanistic link between the hydrogen-dependent changes in neurogenesis and cognitive impairments remains unclear. Thus, continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint.
What the Researchers Found
Consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided.
Biological or Mechanistic Findings
Consumption of hydrogen water ad libitum throughout the whole period suppressed the increase in the oxidative stress markers and prevented cognitive impairment, as judged by all three methods, whereas hydrogen water did not improve cognitive ability when no stress was provided. Because hydrogen gas is unsuitable for continuous consumption, the researchers investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydrogen gas, prevents cognitive impairment by reducing oxidative stress. Thus, continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint.
Authors’ Conclusion
These results are preclinical and add to understanding of how molecular hydrogen affects the condition studied. Further human research is needed to determine its clinical relevance.