Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.
Takaaki Sakai, Bunpei Sato, Koji Hara, Yuichi Hara, Yuji Naritomi, Samon Koyanagi, Hiroshi Hara, Tetsuhiko Nagao, Toru Ishibashi · Vascular health and risk management · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 8 participants, fMD increased in the high-H₂ group (eight males; eight females) from 6.80%±1.96% to 7.64%±1.68% (mean ± standard deviation) and decreased from 8.07%±2.41% to 6.87%±2.94% in the placebo group (ten males; eight females). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence vascular endothelial function.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 8 participants. FMD increased in the high-H₂ group (eight males; eight females) from 6.80%±1.96% to 7.64%±1.68% (mean ± standard deviation) and decreased from 8.07%±2.41% to 6.87%±2.94% in the placebo group (ten males; eight females).
What the Researchers Studied
The researchers studied 8 participants. The study used a randomized, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
The subjects were randomly divided into two groups: the high-H₂ group, who drank high-H₂ water containing 7 ppm H₂ (3.5 mg H₂ in 500 mL water); and the placebo group. After measurement of diameter of the BA and FMD at baseline, volunteers drank the high-H₂ water or placebo water immediately and with a 30-minute interval; FMD was compared to baseline. FMD increased in the high-H₂ group (eight males; eight females) from 6.80%±1.96% to 7.64%±1.68% (mean ± standard deviation) and decreased from 8.07%±2.41% to 6.87%±2.94% in the placebo group (ten males; eight females). The authors concluded that H₂ may protect the vasculature from shear stress-derived detrimental ROS, such as the hydroxyl radical, by maintaining the nitric oxide-mediated vasomotor response.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence vascular endothelial function and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 8 participants. The reported sample size was 8. The study used a randomized, placebo-controlled human clinical trial.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.