Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.
Takaaki Sakai, Bunpei Sato, Koji Hara, Yuichi Hara, Yuji Naritomi, Samon Koyanagi, Hiroshi Hara, Tetsuhiko Nagao, Toru Ishibashi · Vascular health and risk management · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 8 participants, fMD increased in the high-H₂ group (eight males; eight females) from 6.80%±1.96% to 7.64%±1.68% (mean ± standard deviation) and decreased from 8.07%±2.41% to 6.87%±2.94% in the placebo group (ten males; eight females). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence vascular endothelial function in healthy adults.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 8 participants. FMD increased in the high-H₂ group (eight males; eight females) from 6.80%±1.96% to 7.64%±1.68% (mean ± standard deviation) and decreased from 8.07%±2.41% to 6.87%±2.94% in the placebo group (ten males; eight females).
What the Researchers Studied
The researchers studied 8 participants. The study used a randomized, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
The subjects were randomly distributed into two groups – the high-H₂ group (n=16) and the placebo group (n=18). FMD was calculated as follows: FMD ( % ) = ( maximum diameter − diameter at rest ) × 100 / diameter at rest (1) The high-H₂ water (hydrogen water 7.0; Ecomo International Co, Ltd, Iizuka-shi, Fukuoka, Japan) was prepared according to previously described methods. 40 Briefly, hydrogen gas was produced in an acrylic resin tube in an elastic poly(ethylene terephthalate) (PET) bottle filled with 530 mL of water by mixing 75% of metal aluminum grains with 25% of calcium hydroxide (by weight) and 0.5 mL of water. FMD increased in the high-H₂ group (eight males; eight females) from 6.80%±1.96% to 7.64%±1.68% (mean ± standard deviation) and decreased from 8.07%±2.41% to 6.87%±2.94% in the placebo group (ten males; eight females). The authors concluded that H₂ may protect the vasculature from shear stress-derived detrimental ROS, such as the hydroxyl radical, by maintaining the nitric oxide-mediated vasomotor response.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence vascular endothelial function in healthy adults and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 8 participants. The reported sample size was 4. The study used a randomized, placebo-controlled human clinical trial.
Limitations and Safety
Safety information: 40, 41 These observations are indicative of safety of H₂ gas. In contrast, H₂ generates H₂O after reducing the hydroxyl radical; this is the most important property of H₂ that contributes to its safety.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.