[Effect of combination therapy with propofol and hydrogen-rich saline on organ damage and cytokines in a murine model of sepsis].
Yunchuan Hong, Hongguang Chen, Yonghao Yu, Keliang Xie · Zhonghua wei zhong bing ji jiu yi xue · 2017
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In male C57BL/6 mice, the survival rate of animals increased significantly after propofol or hydrogen-rich treatment, and the combined treatment can further increase survival rate to 90%, 75%, 60%, 55%, and 55%, respectively. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in male C57BL/6 mice. The survival rate of animals increased significantly after propofol or hydrogen-rich treatment, and the combined treatment can further increase survival rate to 90%, 75%, 60%, 55%, and 55%, respectively.
What the Researchers Studied
The researchers studied male C57BL/6 mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
The mice of propofol group and propofol and H₂ group were given 50 mg/kg propofol through tail vein at 1 hour and 6 hours after CLP and the mice of H₂ group and propofol and H₂ group were given 5 mL/kg H₂-rich saline i.p. at 1 hour and 6 hours after CLP. The survival rate of animals increased significantly after propofol or hydrogen-rich treatment, and the combined treatment can further increase survival rate to 90%, 75%, 60%, 55%, and 55%, respectively. The authors concluded that both propofol and H₂ can improve the survival rate of sepsis, reduce tissue damage and the release of cytokines, and combined application of the two treatment was better.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was male C57BL/6 mice. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.