Effect of H2 treatment in a mouse model of rheumatoid arthritis-associated interstitial lung disease.
Yasuhiro Terasaki, Mika Terasaki, Satoshi Kanazawa, Nariaki Kokuho, Hirokazu Urushiyama, Yusuke Kajimoto, Shinobu Kunugi, Motoyo Maruyama, Toshio Akimoto, Yoko Miura, Tsutomu Igarashi, Ikuroh Ohsawa, Akira Shimizu · Journal of cellular and molecular medicine · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, H₂ treatment reduced inflammatory, oxidative, and fibrotic lung changes. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in mice. H₂ treatment reduced inflammatory, oxidative, and fibrotic lung changes.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Animals consumed H₂ ‐rich or control water from day 0 until analysis, and they were housed with five mice per cage under standard laboratory conditions, with food and water available ad libitum. Mice consumed H₂ ‐rich or control water from day 0 after the first injection until analysis. H₂ treatment reduced inflammatory, oxidative, and fibrotic lung changes. The authors concluded that 1, 12, 13, 14 ROS such as •OH, superoxide anions, hydrogen peroxide and hypochlorous acid are reportedly formed in the inflamed joints of patients with RA by nicotinamide adenine dinucleotide phosphate oxidase, xanthine oxidase and cytochrome P450 monooxygenase, as well as mitochondrial respiratory chain dysfunction, in chondrocytes, activated macrophages and neutrophils.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The reported sample size was 3. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
Safety information: During the preparation of H₂ ‐rich water, the H₂ concentration in the air was carefully monitored using a H₂ sensor with an alarm for safety. 18 Therefore, H₂ can be widely used as a medical treatment with good efficacy and safety and few side effects.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.