Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia.
Kimihiro Nagatani, Kojiro Wada, Satoru Takeuchi, Hiroaki Kobayashi, Yoichi Uozumi, Naoki Otani, Masanori Fujita, Shoichi Tachibana, Hiroshi Nawashiro · Shock (Augusta, Ga.) · 2012
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
The researchers observed that H₂ treatment significantly (P = 0.0232) improved the 7-day survival rate of mice, from 8.3% (BCCAO group, n = 12) to 50% (BCCAO + H₂ group, n = 10). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in mice. The researchers observed that H₂ treatment significantly (P = 0.0232) improved the 7-day survival rate of mice, from 8.3% (BCCAO group, n = 12) to 50% (BCCAO + H₂ group, n = 10).
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
A total of 160 mice were divided into three groups: sham surgery (sham group), BCCAO without H₂ (BCCAO group), and BCCAO treated with 1.3% H₂ (BCCAO + H₂ group). The researchers observed that H₂ treatment significantly (P = 0.0232) improved the 7-day survival rate of mice, from 8.3% (BCCAO group, n = 12) to 50% (BCCAO + H₂ group, n = 10).
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.ovid.com/jnls/shockjournal/abstract/10.1097/shk.0b013e31824ed57c~effect-of-hydrogen-gas-on-the-survival-rate-of-mice?redirectionsource=fulltextview.