Effect of Hydrogen-Rich Saline on Postoperative Intra-Abdominal Adhesion Bands Formation in Mice.
Zhong Liu, Sanfang Cheng, Changwei Gu, Honghong Pei, Xin Hong · Medical science monitor : international medical journal of experimental and clinical research · 2017
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Independent study record
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H2HUBB TAKEAWAY
In mice, a significant increase of t-PA and decrease of TGF-b1 and PAI-1 in the peritoneal fluids were observed in the HRS-treated groups. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Mice
What the Researchers Found
A significant increase of t-PA and decrease of TGF-b1 and PAI-1 in the peritoneal fluids were observed in the HRS-treated groups.
Authors’ Conclusion
The authors concluded that these results showed that HRS had therapeutic potential for preventing PPAs formation, possibly through balancing the expression of TGF-β1, t-PA, and PAI-1, and inhibiting oxidative stress and inflammation. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.