Effect of Hydrogen-rich Water on Chronic Kappa-carrageenan-induced Colitis in Weaned Female Swiss Albino Mice: A Preliminary Study.
Oumaima Anachad, Wafaa Taha, Hicham Wahnou, Imad Fenjar, Mohamed Rida Salam, Hasnae Zekhnini, Houssam Assoui, Amina Kardoudi, Abdelouaheb Benani, Faiza Bennis, Fatima Chegdani · Recent advances in inflammation & allergy drug discovery · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In this animal study, the authors report that HRW treatment significantly attenuated disease severity by reducing disease activity index, preserving colon length, decreasing pro-inflammatory cytokines, and partially restoring IL10 expression.
What the Researchers Studied
Source-reported study description: Weaned female Swiss albino mice were assigned to four groups: normal control, UC, HRW, and diclofenac.
Source-reported study description: Except for controls, all groups were exposed to kappa-carrageenan in drinking water for three months to induce chronic colitis, followed by a two-week treatment with HRW or diclofenac.
What the Study Found
The authors reported: HRW treatment significantly attenuated disease severity by reducing disease activity index, preserving colon length, decreasing pro-inflammatory cytokines, and partially restoring IL10 expression.
The authors reported: HRW had limited effects on the relative abundance of beneficial gut microbes such as Bifidobacterium spp. and Akkermansia spp.
What the Findings Mean
The authors concluded/reported: this exploratory proof-of-concept study suggests that HRW may represent a promising supportive approach for reducing diet-induced intestinal inflammation during weaning.
Study Details
Publication type: animal_study
Evidence source level: B_ABSTRACT
Original scholarly source: https://pubmed.ncbi.nlm.nih.gov/42439355/