Enzyme-Triggered Size-Switchable Nanosystem for Deep Tumor Penetration and Hydrogen Therapy.
Yongju He, Xiangjie Tian, Xingyu Fan, Xiyu Gong, Songwen Tan, Anqiang Pan, Shuquan Liang, Hui Xu, Fangfang Zhou · ACS applied materials & interfaces · 2023
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Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, pEG is introduced to further increase the particle size and endow the nanoparticle with long blood circulation to achieve effective tumor accumulation via the EPR effect. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
How Molecular Hydrogen Was Used
Herein, taking the advantages of biosafe H₂ and small-sized nanoparticles in diffusion within tumor ECM, the researchers develop a matrix metalloprotease 2 (MMP-2) responsive size-switchable nanoparticle (UAMSN@Gel-PEG) that is composed of ultrasmall amino-modified mesoporous silica nanoparticles (UAMSN) wrapped within a PEG-conjugated gelatin to deliver H₂ to the deep part of tumors for effective gas therapy. Ammonia borane (AB) is chosen as the H₂ prodrug that can be effectively loaded into UAMSN by hydrogen-bonding adsorption. Upon stimulation by the acidic tumor microenvironment, AB decomposes into H₂ for further intratumor diffusion to achieve effective hydrogen therapy.
What Molecular Hydrogen Changed
PEG is introduced to further increase the particle size and endow the nanoparticle with long blood circulation to achieve effective tumor accumulation via the EPR effect.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.