Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy.
Hongguang Chen, Huaying Lin, Beibei Dong, Yaoqi Wang, Yonghao Yu, Keliang Xie · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, pINK1 was required for the mitigation of the cell impairment in LPS-stimulated macrophages by hydrogen treatment. The authors concluded that these results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
The researchers previously demonstrated that hydrogen alleviated the inflammation-induced cell injury and organ damage in septic mice.
What Molecular Hydrogen Changed
PINK1 was required for the mitigation of the cell impairment in LPS-stimulated macrophages by hydrogen treatment.
Proposed Mechanism
Hydrogen inhibited acute lung injury in CLP mice via activation of PINK1-mediated mitophagy. These results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury. These results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.