Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo.
Wenbo Zhang, Chao Huang, Aijun Sun, Liang Qiao, Xi Zhang, Junlong Huang, Xuejun Sun, Xiangqun Yang, Shanquan Sun · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018
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Independent study record
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H2HUBB TAKEAWAY
In As a novel and effective antioxidant, hydrogen has been proved to alleviate cellular senescence in endothelial cells in vitro, the number of senescence-associated β-galactosidase (SA-β-Gal) positive cells was reduced in BMSCs from rats treated with HRS. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
Laboratory Model
As a novel and effective antioxidant, hydrogen has been proved to alleviate cellular senescence in endothelial cells in vitro.
How Molecular Hydrogen Was Used
As a novel and effective antioxidant, hydrogen has been proved to alleviate cellular senescence in endothelial cells in vitro.
What Molecular Hydrogen Changed
The number of senescence-associated β-galactosidase (SA-β-Gal) positive cells was reduced in BMSCs from rats treated with HRS.
Proposed Mechanism
However, the effects and mechanisms of hydrogen on senescence in vivo are still unclear. Subsequently, bone marrow-derived stem cells (BMSCs) were harvested for the detection of hydrogen antisenescence effects and mechanisms. And the underlying mechanism of antisenescence effects of hydrogen in BMSCs was via the ROS/p53/p21 signaling pathway.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.