Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis.
Mikihito Kajiya, Kimihiro Sato, Marcelo J B Silva, Kazuhisa Ouhara, Phi M Do, K T Shanmugam, Toshihisa Kawai · Biochemical and biophysical research communications · 2009
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Independent study record
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H2HUBB TAKEAWAY
in vitro production of both TNF-alpha and IFN-gamma by ConA-stimulated spleen lymphocytes was significantly inhibited by the introduction of H(2), systemic antibiotics significantly decreased the level of H(2) in both liver and intestines along with suppression of intestinal bacteria. The authors concluded that these results indicate that H(2) released from intestinal bacteria can suppress inflammation induced in liver by ConA. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in Furthermore, in vitro production of both TNF-alpha and IFN-gamma by ConA-stimulated spleen lymphocytes was significantly inhibited by the introduction of H(2). Systemic antibiotics significantly decreased the level of H(2) in both liver and intestines along with suppression of intestinal bacteria.
What the Researchers Studied
The researchers studied Furthermore, in vitro production of both TNF-alpha and IFN-gamma by ConA-stimulated spleen lymphocytes was significantly inhibited by the introduction of H(2). The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
Systemic antibiotics significantly decreased the level of H(2) in both liver and intestines along with suppression of intestinal bacteria. The authors concluded that these results indicate that H(2) released from intestinal bacteria can suppress inflammation induced in liver by ConA.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was Furthermore, in vitro production of both TNF-alpha and IFN-gamma by ConA-stimulated spleen lymphocytes was significantly inhibited by the introduction of H(2). The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.