Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation.
Yaxing Zhang, Mingmin Bi, Zifeng Chen, Min Dai, Ge Zhou, Yuxuan Hu, Hongzhi Yang, Weibing Guan · Experimental and therapeutic medicine · 2021
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In mice, H₂ treatment reduced serum TC levels in the Alcohol+H₂ group when compared with those in Alcohol group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
Mice
What the Researchers Found
H₂ treatment reduced serum TC levels in the Alcohol+H₂ group when compared with those in Alcohol group.
Biological or Mechanistic Findings
Hydrogen gas (H₂) serves a key role in the modulation of hepatic redox, immune and inflammatory homeostasis.
Authors’ Conclusion
The authors concluded that it was observed that acute ethanol gavage induced liver injury, as indicated by significantly increased serum ALT and AST levels, which were effectively decreased by H₂ at 16 h after the first ethanol gavage. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.