Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.
Hiroki Matsuoka, Seiko Miyata, Nozomi Okumura, Takuya Watanabe, Katsunori Hashimoto, Miki Nagahara, Kazuko Kato, Sayaka Sobue, Kozue Takeda, Masatoshi Ichihara, Takashi Iwamoto, Akiko Noda · Clinical and experimental hypertension (New York, N.Y. : 1993) · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, iVST, LVPWT, and LV mass were significantly higher in the 8% NaCl group than the 0.3% NaCl group at 12 weeks of age, whereas they were significantly lower in the 8% NaCl + 2% H₂ group than the 8% NaCl group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The purpose of this study was to investigate the effects of H₂ gas on hypertension and LV hypertrophy using echocardiography.
How Molecular Hydrogen Was Used
Dahl salt-sensitive (DS) rats were randomly divided into three groups: those fed an 8% NaCl diet until 12 weeks of age (8% NaCl group), those additionally treated with 2% H₂ gas (8% NaCl + 2% H₂ group), and control rats maintained on a diet containing 0.3% NaCl until 12 weeks of age (0.3% NaCl group).
What the Researchers Found
IVST, LVPWT, and LV mass were significantly higher in the 8% NaCl group than the 0.3% NaCl group at 12 weeks of age, whereas they were significantly lower in the 8% NaCl + 2% H₂ group than the 8% NaCl group.
Authors’ Conclusion
The authors concluded that chronic H₂ gas inhalation may help prevent LV hypertrophy in hypertensive DS rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.