Hydrogen Gas Inhalation Prevents Erythrocyte Aggregation and Promotes Leukocyte Phagocytosis Together with Increases in Serum Antioxidant Activity
Yuki Takada, Nobuhiko Miwa · Hydrogen · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In a laboratory model, thus, 3%-hydrogen gas inhalation is suggested to potentially improve both the erythrocyte rheological/morphologic behaviors and the leucocyte phagocytosis-associated activity, concurrently with the enhanced antioxidant ability in blood. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
The study examined in vitro cell-culture laboratory experiment.
How Molecular Hydrogen Was Used
The 40 min inhalation of 3% hydrogen gas and thereafter 60 min rest were shown to enhance the antioxidant ability in human serum, as evaluated by ORAC (oxygen radical absorbing capacity)-based fluorometry, although scarcely enhanced for air dummy inhalation.
What Molecular Hydrogen Changed
Hydrogen gas inhalation increased the intracellular foreign bodies, being distinguished from vacuole/cyst, in leucocytes, suggesting the hydrogen-activated leukocyte phagocytosis-associated events.
H₂ Mechanisms / Biological Findings
Oxidative stress-suffering erythrocytes formed a rosary-chain-like aggregation composed of 3–6 cells, together with loss of a single hollow/biconcave-discoid structure in the cell central-part being necessary for erythrocyte passing through capillary vessels, both of which were prevented by 3% hydrogen gas inhalation.
Authors’ Conclusion
The authors concluded that 3%-hydrogen gas inhalation is suggested to potentially improve both the erythrocyte rheological/morphologic behaviors and the leucocyte phagocytosis-associated activity, concurrently with the enhanced antioxidant ability in blood.