Hydrogen Gas Inhalation Regressed Coronary Artery Aneurysm in Kawasaki Disease-Case Report and Article Review.
Ho-Chang Kuo · Frontiers in cardiovascular medicine · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In this report, the researchers showed a KD patient with an aneurysm over the right coronary artery with a size of 6.08 mm in diameter and 35 mm in length, which completely regressed to within normal range after hydrogen inhalation within 4 months after disease onset. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in No effective treatment is currently available for aneurysm formation in KD. In this report, the researchers showed a KD patient with an aneurysm over the right coronary artery with a size of 6.08 mm in diameter and 35 mm in length, which completely regressed to within normal range after hydrogen inhalation within 4 months after disease onset.
What the Researchers Studied
The researchers studied No effective treatment is currently available for aneurysm formation in KD.
What Effects Did Molecular Hydrogen Have?
Although these data suggest that inhaled hydrogen gas may be well tolerated, future studies need to be powered to further evaluate safety especial in children ( 21 ). In this report, the researchers showed a KD patient with an aneurysm over the right coronary artery with a size of 6.08 mm in diameter and 35 mm in length, which completely regressed to within normal range after hydrogen inhalation within 4 months after disease onset. The authors concluded that coronary artery aneurysm formation is the most severe complication of KD and may have life-long implications. Ohsawa et al. ( 16 ) reported that hydrogen gas, an inert gas, is an effective antioxidant that contributes to the regulation of oxidative stress and inflammation response. Zhang et al. also reported that post-conditioning with hydrogen gas ameliorated subarachnoid hemorrhage (SAH)-induced, which is predominantly caused by a ruptured aneurysm, neuronal pyroptosis in part through the mitochondrial ATP-sensitive K+ channels/ERK1/2/p38 MAPK signaling pathway ( 20 ).
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a case report. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as case report with human clinical evidence. The research population or model was No effective treatment is currently available for aneurysm formation in KD. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.