Hydrogen Research Study
← Back to Research Library
Laboratory or cellular evidenceLaboratory StudyOther or not reported

Hydrogen gas inhibits lung cancer progression through targeting SMC3.

Dongchang Wang, Lifei Wang, Yu Zhang, Yunxia Zhao, Gang Chen · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018

Research-use notice

Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

H2HUBB Research Library branded molecular hydrogen research image
Primary topic Molecular Hydrogen Overview
Evidence type Laboratory or cellular evidence
Publication type Laboratory Study
Hydrogen method Other or not reported

H2HUBB TAKEAWAY

In a laboratory model, the expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H₂ or cis-platinum, especially for cis-platinum. The authors concluded that all data suggested that H₂ inhibited lung cancer progression through down-regulating SMC3, a regulator for chromosome condensation, which provided a new method for the treatment of lung cancer. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.

What the Researchers Tested

In vitro cell-culture laboratory experiment.

How Molecular Hydrogen Was Used

The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H₂ or cis-platinum, especially for cis-platinum.

What Molecular Hydrogen Changed

The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H₂ or cis-platinum, especially for cis-platinum.

Authors’ Conclusion

These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.