Hydrogen gas inhibits lung cancer progression through targeting SMC3.
Dongchang Wang, Lifei Wang, Yu Zhang, Yunxia Zhao, Gang Chen · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
In a laboratory model, the expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H₂ or cis-platinum, especially for cis-platinum. The authors concluded that all data suggested that H₂ inhibited lung cancer progression through down-regulating SMC3, a regulator for chromosome condensation, which provided a new method for the treatment of lung cancer. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
How Molecular Hydrogen Was Used
The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H₂ or cis-platinum, especially for cis-platinum.
What Molecular Hydrogen Changed
The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H₂ or cis-platinum, especially for cis-platinum.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.