Hydrogen gas presents a promising therapeutic strategy for sepsis.
Keliang Xie, Lingling Liu, Yonghao Yu, Guolin Wang · BioMed research international · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. Meanwhile, combination therapy with H₂ (2%) and hyperoxia (98%) increases the 14-day survival rate of moderate sepsis mice to 100% and the 7-day survival rate of severe sepsis mice from 0% to 70% and alleviates injuries of lung, liver, and kidney in moderate and severe sepsis [ 41 ]. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Meanwhile, combination therapy with H₂ (2%) and hyperoxia (98%) increases the 14-day survival rate of moderate sepsis mice to 100% and the 7-day survival rate of severe sepsis mice from 0% to 70% and alleviates injuries of lung, liver, and kidney in moderate and severe sepsis [ 41 ].
What the Researchers Studied
The authors reviewed hydrogen gas presents a promising therapeutic strategy for sepsis.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2% source-reported H₂ gas concentration; reported treatment duration: 1 hour. Meanwhile, combination therapy with H₂ (2%) and hyperoxia (98%) increases the 14-day survival rate of moderate sepsis mice to 100% and the 7-day survival rate of severe sepsis mice from 0% to 70% and alleviates injuries of lung, liver, and kidney in moderate and severe sepsis [ 41 ]. The authors concluded that recently, vigorous experimental studies have been undergone to identify effective therapy of molecular hydrogen for sepsis. However, the researchers should deeply proceed to more experimental researches to investigate the plausible and comprehensive mechanisms of hydrogen to treat sepsis. it has been suggested to use molecular hydrogen as a new anti-inflammatory strategy.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The source-reported hydrogen concentration was 2% source-reported H₂ gas concentration. The reported treatment duration was 1 hour.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.