Hydrogen Gas via Extracorporeal Membrane Oxygenation and Its Effects on Oxidative Stress, Coagulation, and Inflammation: An Ex Vivo Model.
Lucia Gandini, Keibun Liu, Margaret R Passmore, Chris H H Chan, Emily S Wilson, Shinichi Ijuin, Angelo Milani, Kieran Hyslop, Nicole White, Binuri Perera, Nchafatso Obonyo, Mahe Bouquet, Gianluigi Li Bassi, John F Fraser, Jacky Y Suen · ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In This ex vivo study investigated whether ECMO could serve as an effective vehicle for hydrogen delivery, hydrogen exposure significantly reduced collagen (p = 0.01), TRAP-6 (p = 0.04), and ADP-induced (p = 0.04) platelet aggregation and showed a trend toward reduction in oxidative stress markers. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in This ex vivo study investigated whether ECMO could serve as an effective vehicle for hydrogen delivery. Hydrogen exposure significantly reduced collagen (p = 0.01), TRAP-6 (p = 0.04), and ADP-induced (p = 0.04) platelet aggregation and showed a trend toward reduction in oxidative stress markers.
What the Researchers Studied
The researchers studied This ex vivo study investigated whether ECMO could serve as an effective vehicle for hydrogen delivery. The study used a laboratory experiment.
What Effects Did Molecular Hydrogen Have?
This ex vivo study investigated whether ECMO could serve as an effective vehicle for hydrogen delivery. It also evaluated hydrogen's effects on oxidative stress, inflammation, and coagulation responses arising from the interaction between human blood and non-biological ECMO surfaces. Hydrogen exposure significantly reduced collagen (p = 0.01), TRAP-6 (p = 0.04), and ADP-induced (p = 0.04) platelet aggregation and showed a trend toward reduction in oxidative stress markers.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was This ex vivo study investigated whether ECMO could serve as an effective vehicle for hydrogen delivery. The reported sample size was 4. The study used a laboratory experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.