Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers.
Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Masaki Sakamoto, Yohei Kudo, Jun Nakazawa, Kumi Kaneko, Atsunori Nakao · Medical gas research · 2012
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 4 patients, erythema of these 4 patients and associated symptoms improved significantly after the H₂ treatment and did not recur. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 4 patients. Erythema of these 4 patients and associated symptoms improved significantly after the H₂ treatment and did not recur.
What the Researchers Studied
The researchers studied 4 patients. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
All of the four patients received intravenous administration of 500 ml of H₂ enriched fluid in 30 min for more than 3 days except in one patient for only once. Erythema of these 4 patients and associated symptoms improved significantly after the H₂ treatment and did not recur. The authors concluded that the H₂ delivery study of two volunteers suggested initial direct delivery and additional prolonged delivery possibly from a slowly desaturating reservoir in the skin to the surface.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 4 patients. The reported sample size was 4. The study used a human clinical study.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.